DAILY FOUNDATION

Nicotinamide riboside (NR), a form of vitamin B3, it can boost cellular metabolism and longevity through its role as a precursor to nicotinamide adenine dinucleotide (NAD+). NAD+ is crucial for cellular energy production and is involved in hundreds of metabolic processes. As cells age, NAD+ levels naturally decline, which is linked to age-related degenerative diseases. (study, study)

NR enhances NAD+ synthesis, supporting the repair of DNA, improving mitochondrial function, and activating proteins associated with aging (sirtuins). Sirtuins play significant roles in regulating oxidative stress, maintaining mitochondrial efficiency, and ensuring proper cell function, which can slow down aging processes and reduce the risk of metabolic and chronic diseases. (study, study, study)

Increasing NAD+ levels through NR supplementation can improve energy metabolism, enhance physical performance, and increase resilience against neurodegenerative diseases. It supports brain health by maintaining neuronal function and protecting against cognitive decline. (study)

The body uses ATP (adenosine triphosphate) as an energy source. ATP is produced in two steps, i.e., Kreb’s cycle and oxidative phosphorylation. Kreb’s cycle involves the breakdown of glucose into smaller molecules, alpha-ketoglutarate being one of those small molecules. It can kick-start energy production at the cellular level by providing fuel to Kreb’s cycle.

Nicotinamide adenine dinucleotide hydride (NADH) is the molecule that captures energy when cells use alpha-ketoglutarate. It is then used to generate ATP. NADH can be utilized directly as an energy source as well, however, cells can only be used for limited functions. Therefore, its energy is generally converted to ATP (study, study, study, study)

Coenzyme Q10 (CoQ10), also known as ubiquinone, has key roles in cellular energy production and antioxidant protection. Located in the mitochondria, CoQ10 is integral to converting substrates into ATP through the electron transport chain, supporting vital cellular functions and overall energy levels. (study, study)

Its antioxidant function is critical for neutralizing free radicals, unstable molecules that damage cells and contribute to aging and diseases, including cardiovascular and neurodegenerative disorders. This protection is crucial for mitigating oxidative stress linked to these conditions. (study)

CoQ10 enhancesheart healthby boosting energy production in cardiac cells and supporting endothelial function, which can help manageblood pressure and heart failure. It also benefits neurological health by potentially aiding in the prevention and management ofParkinson’s and Alzheimer’s diseases.(study)

Alpha-ketoglutarate (AKG) is a key intermediate in the Krebs cycle, the metabolic pathway that generates energy through the oxidation of nutrients. By facilitating the efficient conversion of carbohydrates, fats, and proteins into energy, AKG plays a pivotal role in maintaining cellular energy levels, which supports overall vitality and physical stamina. (study, study)

One of the notable functions of AKG is its role in amino acid synthesis and nitrogen transport. It acts as an ammonia scavenger, converting glutamate into glutamine in a process that detoxifies ammonia, a compound that can be detrimental at high levels. This detoxification is crucial for maintaining a healthy brain function and muscle physiology. (study, study)

AKG is involved in collagen synthesis and the production of other connective tissues. This activity supports skin, joint, and bone health, aligning with the product's promises of enhancing overall well-being and longevity. The role of AKG in promoting collagen synthesis also suggests its utility in wound healing and tissue repair processes, enhancing recovery from physical stress or injury. (study, study)

Research indicates that AKG may extend lifespan and delay aging-related molecular changes by influencing key signaling pathways associated with cellular aging. These effects include reducing oxidative stress, improving mitochondrial function, and modulating gene expression related to cellular repair mechanisms. (study)

Fisetin, a bioactive flavonol found naturally in fruits and vegetables like strawberries, apples, and grapes, plays a crucial role in enhancing cellular functions and longevity. Research highlights its potent anti-inflammatory and antioxidant properties, significantly impacting health by scavenging harmful free radicals and reducing oxidative stress, conditions linked with chronic diseases including neurodegenerative disorders and cancer.  (study, study, study)

In clinical studies, fisetin has been shown to inhibit the oxidative modification of low-density lipoprotein (LDL), a key factor in the development of atherosclerosis. By inhibiting LDL oxidation by up to 20%, fisetin contributes to the prevention of plaque formation in arteries, thus supporting cardiovascular health. Additionally, fisetin's ability to modulate signaling pathways, particularly those involved in inflammation and aging, underscores its potential as a therapeutic agent, enhancing overall cellular function and longevity. This aligns with the objectives of promoting healthy aging and managing chronic health conditions, making it a critical component in the formulation of supplements aimed at maintaining optimal health and wellness. (study, study)

L-Carnosine, a naturally occurring dipeptide composed of β-alanine and L-histidine, serves critical roles in human physiology, particularly noted in skeletal muscle, brain, heart, and gastrointestinal tissues. Recognized primarily for its antioxidative capabilities, carnosine scavenges free radicals and buffers cellular pH, which aids in maintaining the integrity and functionality of cellular processes. Its significant anti-inflammatory and neuroprotective properties further enhance its potential in therapeutic applications. (study, study)

Research underscores carnosine’s ability to modulate glycation processes and chelate heavy metals, providing a protective mechanism against age-related and degenerative diseases. Carnosine's effect on enhancing the antioxidant capacity of cells is critical in combating oxidative stress, a key factor in the progression of many chronic conditions, including cardiovascular and neurodegenerative diseases. (study, study)

Carnosine has been demonstrated to prolong cell life and support cellular homeostasis, which positions it as a beneficial additive in functional foods aimed at promoting health and longevity. Its ability to cross the blood-brain barrier suggests potential for addressing neurological health, enhancing brain function, and protecting against cognitive decline. The current research trajectory points towards exploring carnosine's beneficial impacts on vascular function and its possible role in mitigating endothelial dysfunction in cardiovascular diseases, marking it as a potent candidate for future health-related interventions and clinical applications. (study)

L-Theanine, predominantly found in green and black tea, is renowned for its ability to enhance relaxation without sedation. This amino acid significantly reduces anxiety and stress, particularly in high-pressure environments, while improving focus and cognitive function, especially when combined with caffeine. It has proven effects on immune health, reducing the frequency of upper respiratory infections and improving inflammation markers in the gastrointestinal tract. (study, study, study)

Research also suggests that L-theanine may amplify the effects of chemotherapy drugs, hinting at potentialanti-cancer properties. Moreover, L-theanine can stabilize blood pressure under stress and is linked to better sleep quality in individuals with psychological disorders and ADHD, without inducing drowsiness. (study, study, study)

Inositol, often referred to as vitamin B8, is a pseudovitamin compound that plays a critical role in cellular processes and neurotransmitter regulation. It functions as a vital component of cell membranes and acts as a secondary messenger in several biological processes, particularly in insulin signal transduction. This makes it integral to managing insulin sensitivity and glucose metabolism, supporting its potential use in addressing conditions like metabolic syndrome and diabetes. (study)

In the context of mental health, inositol impacts neurotransmitter functions, especially serotonin and dopamine, which are crucial for mood regulation. This property underpins its use in potentially alleviating symptoms of psychological conditions such as anxiety, depression, and panic disorder. Research suggests that inositol can modulate brain signaling pathways, thereby exerting anxiolytic and antidepressant effectswithout the sedative side effects often associated with other treatments. (study, study)

Rhodiola Rosea, known as golden root, is valued for its adaptogenic properties, aiding the body in combating various stressors. This herb enhances mental and physical endurance, reduces fatigue, and supports cognitive functions such as focus and memory. Studies show that Rhodiola balances the body’s stress-response by modulating neurotransmitters like serotonin and dopamine. It inhibits their breakdown and enhances their brain transport, improving mood and reducing mental fatigue. (study, study)

Furthermore, Rhodiola increases energy metabolism and red blood cell count, which helps transport oxygen to muscles, thus enhancing physical performance and shortening recovery times after exercise. (study, study)

Resveratrol, extensively studied for its cardiovascular benefits, has shown substantial potential in enhancing heart health through several mechanisms. Notably, it may reduce systolic blood pressure by promoting increased production of nitric oxide, which helps relax and dilate blood vessels, reducing arterial stiffness (a common concern with aging). (study, study, study)

This compound also exerts a favorable effect on lipid profiles. A study highlighted that after six months of treatment with a resveratrol-enriched grape extract, participants experienced a significant reduction in LDL cholesterol by 4.5% and a reduction in oxidized LDL by 20% compared to those receiving a placebo or an unenriched extract. This reduction in oxidized LDL is particularly important as it plays a crucial role in the pathogenesis of atherosclerosis, leading to reduced plaque formation in arteries. Additionally, resveratrol's neuroprotective capabilities contribute to cognitive health, offering protection against the accumulation of beta-amyloid plaques, which are linked to Alzheimer’s disease. (study, study, study)

Lemon Balm Extract, derived from the herb Melissa officinalis, is recognized for its calming effects on the nervous system. It primarily aids in reducing anxiety and promoting sleep by increasing the availability ofgamma-aminobutyric acid (GABA), a neurotransmitter that promotes relaxation. (study, study)

Clinical studies suggest that Lemon Balm can alleviate symptoms of stress and enhance mood by inhibiting the enzyme that degrades GABA, leading to increased levels in the brain, which helps in managing stress and anxiety more effectively. (study, study)

Additionally, Lemon Balm has been shown to possess antioxidant properties, helping to combat oxidative stress and support cellular health. (study)

Magnesium is a cofactor in over 300 enzymatic reactions, magnesium's primary function involves energy production, nucleic acid synthesis, and the regulation of neuronal and muscle function, including the crucial role it plays in nerve transmission and muscle contraction. (study)

Biochemically, magnesium is essential for the proper function of ATP, the energy currency of the cell, as it stabilizes ATP in its biologically active form. This stabilization is crucial for ATP-dependent processes, which include nearly all cellular functions, from DNA replication to muscle contractions and nerve signal transmission. By supporting ATP functionality, magnesium directly enhances cellular energy levels, promoting vitality and stamina, which are essential for the body's daily functions and stress responses. (study, study)

Magnesium modulates cellular events involved in inflammation. It does this by influencing the activity of cells involved in the inflammatory response. For instance, it can inhibit the activation of NMDA receptors, which play a role in the neural transmission of pain and inflammation. By blocking these pathways, magnesium can help manage inflammatory conditions, contributing to its anti-inflammatory properties. (study, study)

Magnesium's ability to regulate neurotransmitter synthesis and release helps maintain mental function, supporting the product's aim to enhance cognitive abilities and mental calmness. It aids in managing stress and anxiety by participating in the synthesis of serotonin. (study, study)